- Gastroparesis, a disorder of gastrointestinal motility, is a syndrome characterized by delayed emptying of the stomach
- It is estimated to affect up to 5 million individuals in the US1
- Diabetes (including both type 1 and type 2) is the most common known cause of gastroparesis2
- Symptoms include1:
- Abdominal pain
- Postprandial fullness (feeling full long after finishing a meal)
- Early satiety (feeling full after consuming only a small amount of food
- Gastroparesis is an important complication of long-term diabetes and is associated with significant impact on health, well-being, and possibly lifespan3
- Vomiting from gastroparesis, as well as delayed gastric emptying itself, may cause significant difficulties in adjusting medications to achieve glucose control in affected diabetic patients3,4
- Management goals are rarely met with current therapies, which can be limited by adverse events3
- No new medications have been approved in three decades, and development of new and effective pharmacologic therapies is a major unmet need3
1 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). https://www.niddkrepository.org/studies/gpcrc/. Accessed April 20, 2018.
2 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). https://www.niddk.nih.gov/health-information/digestive-diseases/gastroparesis. Accessed April 20, 2018.
3 Lembo A, et al. Gastroenterology. 2016;151(1):87-96.
4 American Diabetes Association (ADA). http://www.diabetes.org/living-with-diabetes/complications/gastroparesis.html. Accessed July 25, 2019